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Tissue imaging mass spectrometry permits high-resolution spatial localization of metabolites, proteins and drugs within tissue sections in situ, allowing assessment of metabolic changes at the cellular level. When mass spectrometry images are overlaid onto conventional histology images it is possible to determine the molecules that correlate with tissue pathology, cell type, drug distribution and toxicity. This technique is particularly applicable to cancer research where molecules can be characterized with tumor cells and their microenvironment, allowing direct therapeutic effects to be assessed. Please join the Yale School of Public Health for this symposium, that will explore advances and challenges in tissue imaging mass spectrometry.

Agenda

Vasilis Vasiliou, Professor & Chair, Dept. Environmental Health Sciences, Yale School of Public Health, Yale Cancer Center
Introduction

Keynote Speaker: Richard Caprioli, Professor of Biochemistry, Director of the Mass Spectrometry Research Center, Vanderbilt University School of Medicine
Imaging Mass Spectrometry: Molecular Microscopy for Biological/Clinical Research,  Abstract

Richard Goodwin, Principal Scientist – Mass Spectrometry Imaging, AstraZeneca
The Role of Mass Spectrometry Imaging in Oncology Drug Discovery

Stephen Castellino, Senior GSK Fellow and Head of US Ex Vivo Imaging, GlaxoSmithKline
Imaging MS: Visualizing Drug Disposition and Pharmacology in Tissue,  Abstract

Kirill A. Veselkov, Department of Surgery and Cancer, Imperial College London
Translational Data analytics for large-scale MSI data

Kevin L. Schey, Professor of Biochemistry and Ophthalmology & Visual Sciences, Deputy Director of Research, Imaging Mass Spectrometry Center, Vanderbilt University School of Medicine
Imaging Mass Spectrometry of Ocular Tissues: Molecular Signatures of Aging and Disease,  Abstract

Per E. Andrén, Professor of Mass Spectrometry Imaging, Director of National Resource for Mass Spectrometry Imaging, Dept. of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden
Mapping the Brain Neurotransmitter Network with Mass Spectrometry Imaging Directly in Tissue Sections,  Abstract

Michael Angelo, Assistant Professor, Department of Pathology, Stanford University School of Medicine
High Dimensional IHC in Clinical Tissue bBopsies Using Multiplexed Ion Beam Imaging

Sheerin K. Shahidi-Latham, Head of Metabolomics & Imaging MS, Drug Metabolism & Pharmacokinetics Department, Genentech, Member of the Roche Group
High-Resolution Imaging MALDI Mass Spectrometry to Support Drug Discovery and Development

Roundtable chaired by Mark Duncan and Caroline Johnson

Lunch and wine and cheese reception included. Admission is free.