A research team led by Edison Liu, M.D., president and CEO of The Jackson Laboratory, has found a molecular fingerprint of some of the most deadly cancers of women: a genomic configuration described as a tandem duplicator phenotype (TDP) that is significantly enriched in triple-negative breast cancer, serous ovarian cancer and endometrial carcinomas, and that responds to a specific chemotherapy.

In a paper in the Proceedings of the National Academy of Sciences, the researchers showed that the TDP’s characteristics include genome-wide disruption of cancer genes, loss of cell cycle control and DNA damage repair, and increased sensitivity to cisplatin, a platinum-based chemotherapy.

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