Vascular tumors are the most common abnormal growths in infants and children, affecting 5%-10% of newborns. Some of these tumors remain resistant to pharmacological therapies and require surgery.

In a new study, a team of Yale-led researchers identified specific mutations in the GNA14 and GNA11 genes within these unresponsive tumors, and revealed that these mutations act via a chain of proteins known as the MAPK pathway.

The findings raise the possibility for developing novel therapeutic approaches for these growths.